Type 2 diabetes (T2DM) is caused by overeating, particularly high glycemic index carbohydrates. I’ve reviewed non-communicable disease causation, including diabetes, for 30 years. Almost all are being caused by chronic, aberrant activation of an immune system ‘master molecule’, called NF-kB. This includes T2DM.
A major contributory factor in the activation NF-kB is chronic receptor stimulation. In T2DM, it is the insulin receptor which is chronically activated. Many other genetic and environmental factors contribute. Genetic factors include immune system, enzyme and receptor polymorphisms. Environmental factors include chemical exposure, infection by latent intracellular pathogens, lack of vitamin D, sedentary lifestyle, gut microbiota, as well as diet.
I’ve written a blog with more than 900 links to PubMed papers which explains why chronic, aberrant NF-kB activation occurs, and how this results in many different diseases, depending on the cell type in which the activation occurs. T2DM is one of the diseases covered.
When I was 2 years old< I was diagnosed with food allergies. Under 2 doctor’s care, I spent 12 years on an incredably restrictive diet to aoid the fruits and vegtables I was allerigc to. As a result, I was incredably thin. After age 14, I was retested, and some fruits and veggies I was allowed to eat, as well as cows milk. My allergist at the time told my mother I should be monitored for diabetes, as his experience showed him that many children with food allergies developed type 2. She refused and I developed Type 2 as an adult. There needs more studies and less name calling.
The best way to avoid diabetes is to eat like you already have it. That is 3 well-timed, well-balanced, carb-controlled (low glycemic index, whole fruits, vegetables, portion controlled) meals per day. Insist that your doctor check your fasting glucose, fasting insulin, A1c, and lipid profile. Knowing your fasting glucose without knowing your fasting insulin is like trying to decide if you are fat based on your weight without knowing how tall you are.
I was diagnosed as diabetic 9 years ago, at the age of 80. I had seen my grandfather and father die from heart disease related o diabetese, and I knew I had to do something.
My internist proscribed home glucose testing and using the result to guide the dosage of a medicine I know as Starlix; it also sells by other names. I lost 30 pounds in afew months, and then lost another 20 pounds slowly until I reached what my internist thinks is optumum. My blood sugar values rarely go over 110;105 is optimal. My Hemoglobin A1C levels are tested every 6 months now. The test reports were right at thetarget – 105, but inthe last year it has gone down alittle more.
It isn’t hard. There are many foods with no sugar or only small amounts. It would be better if restarants recognized that mny more diners would offer diabetic deserts. Cruiseships do it. But diabetic meals n planes offer include rice, whic diabetics should not eat. Rice starch very quickly breaks down to glucose in thedigestive system.
The goal isn’t to eliminte blood sugar. It needs to be balanced.
I know diabetics who overeat sugary foods except when they will see their doctor in a few days. I’m sorry for them.
If you get diabetes for the first time in your sixties there may be no change in expected mortality and you’re probably dead before adverse consequences appear.
“Dr. Seaquist…emphasized that modest weight loss can help. You don’t have to lose 100 pounds to prevent diabetes.” A loss of 7 percent to 10 percent of body weight can be effective.” And “Moderate activity, 30 minutes a day five or more days a week, is helpful.”
Well, actually no. Emphatically no. Large-scale, long-term randomized controlled trial no.
Take a look at the recent 10-year, 16-U.S.-study-center “Look AHEAD” trial. See: “Cardiovascular Effects of Intensive Lifestyle Intervention in Type 2 Diabetes,” N Engl J Med 2013; 369:145-54. “Conclusions – An intensive lifestyle intervention focusing on weight loss [through diet and exercise] did not reduce the rate of cardiovascular events in overweight or obese adults with type 2 diabetes.”
The intervention group did indeed lose a bit of weight. But all of that intensive lifestyle weight loss and exercise intervention produced NO net cardiovascular gain after nearly 10 years. Disappointing, certainly, but at least it’s definitive.
What is the definition of insanity–when you keep trying the same thing over and over again and expect to see different results?
I was diagnosed in late-January. My blood-sugar levels have been normally not too high, though I have spiked a couple of times. A few times I was even low and got to have a small glass of orange juice each time. (That is what I miss the most.) We have found acceptable substitutes for my goodies, but I full well realize that I need to do more. I’ve taken a break from the twice per week swimming, though it’s really more like exercise in the pool, in that I have never been a good simmer. But I have gone down about 30 pounds since late January. A little more would be better though.
One way to halt the trend toward obesity and diabetes is to make marijuana, a powerful appetite stimulant, illegal to use without a prescription.
It is necessary to look at the data death rate on diabetes expressed as 100,000 per age-standardized population, reported by the World Health Organization.
Country, Prevalence, Life Expectancy (years)
United States, 15.6, 78.6; United Kingdom, 5.04; Greece 5.01; Mauritius, 176.03; Seychelles, 127; Russia, 4.81; Japan, 4.53; and China 13.42.
Using the latest data from the CDC, there is variation among the states, from 32.93 in West Virginia to 13.32 in Massachusetts. In addition, there is variance among counties in both states: In the former, the prevalence in Berkshire county is 21.94 and 9.45 in Nantucket. In the latter, it is 61.24 in McDowell and 11.46 in Grant County, WVA.
As a Black West Indian American with a family history of diabetes, I suggest that the high prevalence of diabetes in the North America is primarily a result of genetics. This is based on the high prevalence in Africa, ranging from a high in Mauritius to a low of 127 in Seychelles.
Here are the data:http://www.worldlifeexpectancy.com/north-america/diabetes-mellitus-cause…
Trinidad 118.39; Mexico, 83.82; St. Kitts, 80.14; St. Lucia, 79.22; Antigua, 65.69; Haiti, 62.74; Dominica, 62.21; Grenada, 61.48; St. Vincent, 55.95, Barbados, 55.84; Dominican Rep., 41.97; Bahamas, 37.25; United States, 15.16; Cuba, 14.23; and Canada, 13.41.
We eat a whole lot of manufactured chemically added food. With two parents both working, or in the case of single Moms with kids on there own, not rocket science to figure out, whatever is fattest on the table, is the order of the day. Spendin a lot of time and it is time consuming preparing wholesome meals is not our bag in our culture.